A large number of inflammatory cytokines continuously stimulate HSCs, inducing activation, proliferation, and the secretion of many fibrosis cytokines, including α-SMA, TGF-β, collagen-I, and Collagen ...

The gross proceeds from the initial public offering are expected to be approximately $191 million, before deducting underwriting discounts and commissions and other offering expenses, and excluding ...

Hepatic fibrosis is a reversible wound healing response characterized by accumulation of extracellular matrix (ECM), or "scar," that follows chronic but not self-limited liver disease. The ECM ...

New York, USA, Jan. 28, 2025 (GLOBE NEWSWIRE) -- Pulmonary Fibrosis Clinical Trial Pipeline Appears Robust With 110+ Key Pharma Companies Actively Working in the Therapeutics Segment | DelveInsight ...

Lipid peroxidation products are emerging as important stimuli to ECM production ... efforts to use antioxidants as therapy for hepatic fibrosis (see section on Therapy of Hepatic Fibrosis ...

On the other hand, the increased miR-133 also suppresses ERG-encoded IKr channels, eventually aggravating electrical remodeling. Cardiac fibrosis is distinguished by the excess deposition of ECM and ...

Lung fibrosis is a progressive disease characterized by excessive extracellular matrix (ECM) deposition, causing lung tissue stiffness and breathing difficulties. Although pirfenidone and ...

Learn about cystic fibrosis, a genetic disorder that affects the lungs, pancreas, and other organs, and how to treat and live with this chronic disease. 12 min read What Is Cystic Fibrosis? Cystic ...

New York, USA, Jan. 28, 2025 (GLOBE NEWSWIRE) -- Pulmonary Fibrosis Clinical Trial Pipeline Appears Robust With 110+ Key Pharma Companies Actively Working in the Therapeutics Segment ...

This migratory function, the ability to contract the wound area and the production of extracellular matrix (ECM) by intestinal myofibroblast cells certainly have important roles in the physiological ...