Small-molecule enzyme-inhibitors often display insufficient ... of the target protein is used as the template (for example, the N- or C-terminal 5–10 amino acids), the resulting MIP may ...

11) and our understanding of ACE made a compelling argument for a new attempt at designing small molecular weight inhibitors. We had at our disposal not only an enzyme assay but also a highly ...

Angiotensin converting enzyme inhibitors and angiotensin receptor blockers are commonly used to treat hypertension and/or a range of progressive end-organ diseases. The success of each of these ...

Angiotensin converting enzyme inhibitors are a class of oral medications that act primarily through blockade of the angiotensin converting enzyme. This enzyme converts angiotensin I to angiotensin II.

Influencing their activity can control their rates of reaction. Different chemicals can influence enzyme activity. Inhibitors can be used to stop an enzyme from binding to its substrate.

ACE inhibition is a sufficiently well accepted treatment modality, and most of the guidelines addressing treatment of hypertension, renal disease, and/or cardiovascular disease have this ...