Background: Upper motor neuron-dominant ALS (UMND ALS) is recognized to have early onset and good prognosis, but may have a rapid decline in motor function due to gait instability in the early stage.

Motor neuron disease (MND) refers to a group of adult-onset neurodegenerative conditions leading to the degeneration of upper and/or lower motor neurons. MND clinically manifests as a progressive loss ...

But the voices represent a vast improvement on previous communication technologies and are already improving the lives of people with motor neuron diseases, says Richard Cave, a speech and ...

Pain is an example of an important sensory neuron. When you feel pain from a hot pan or a sharp pin, you are sending sensory information via sensory neurons up to the brain. The flow of electrical ...

It causes weakness in the lower part of the face. Peripheral facial nerve paralysis is caused by a problem affecting the nerve. It causes weakness in the whole face, including the forehead. The facial ...

Both biochemical and physical effects of exercise are equally important for promoting nerve growth. This study highlights that biochemical and physical factors have roles in the neuron stage ...

Similarly, in a disease defined by involvement of the upper and lower motor neuron, with or without fronto-temporal dementia, determination of how, whether and when fasciculations may arise in the ...

Contact between a motor neuron and muscle cell is usually via a specialized synapse called a neuromuscular junction. Improved muscle function, strength and fatigue measures were observed after ...

A combination of upper and lower motor neuron dysfunction comprises the clinical ALS phenotype. Although the ALS phenotype was first observed by Charcot over 100 years ago, the site of ALS onset and ...

These common injuries with potentially devastating results provide ongoing stimulus for researchers striving for improved understanding of peripheral nerve biology and its application to nerve repair.

In 2021, researchers worked out that a major cause of damage to motor neuron cells was the loss of a protein called UNC13A, which helps nerve cells pass messages to each other. In patients with MND, ...