Using an intracardiac melanoma metastasis mouse model and RNA sequencing, the team identified significant alterations in gene expression, particularly in ferroptosis-related pathways. A key discovery ...

Melanoma, one of the most aggressive forms of skin cancer, often metastasizes to bones, causing severe bone loss, an increased risk of fractures, and significant pain. Bone metastasis is associated ...

A recent study has uncovered the molecular mechanisms behind osteocyte death in melanoma bone metastasis, revealing that ferroptosis—an iron-dependent form of cell death—plays a central role in the ...

Department of Pulmonary Disease (Department of Respiratory and Critical Care Medicine), Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, China Ferroptosis is a novel form of cell ...

C-MYC suppresses ferroptosis via the autophagy of ferritin mediated by NCOA4, thereby decreasing ROS and preventing mitophagy in ovarian cancer cells (Jin Y et al., 2022). And in hepatocellular ...

Department of Laboratory Medicine, Dongguan Institute of Clinical Cancer Research, The Tenth Affiliated Hospital (Dongguan People’s Hospital), Southern Medical University, Dongguan, Guangdong 523058, ...

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, P.R. China University of the Chinese ...

Ferritin cutoffs for testing are highly variable in primary care and significantly impact the diagnosis and treatment of iron deficiency in this setting. Compared with a ferritin cutoff of 15 ng/mL, ...

Ferritin is a crucial protein that aids in storing iron in the body and plays a significant role in assuring iron equilibrium and ensuring efficient cell functions with the provision of necessary ...

In hepatocytes, ferroptosis faces physiological constraints due to the liver's multilayered antioxidant systems. These include ferritin-mediated iron sequestration, GPx4 activity, and high levels ...