With only a handful of pathways (Fgf, Hedgehog, Wnt, TGFß, Notch among the most important) and few intracellular effector cascades (for example MAPK) the embryos build all the complex organs ...

potentially creating a more complete and durable anti-tumor response through maximal RAS/MAPK pathway inhibition. In contrast to currently available MEK-only inhibitors, avutometinib blocks both MEK ...

Southwest United Graduate School, Yunnan Key Laboratory of Cell Metabolism and Diseases, State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan Center for Life Sciences, ...