SYK-dependent signals from the pre-BCR then feed into the PI3K pathway through CD19 and/or BCAP, leading to the activation of PKB and, in turn, to the inactivation of FOXO transcription factors.

In this study, we investigated the expression changes and interactions between miR4298 and lncKRTAP5-6-3 in chronically UVB-damaged human keratinocyte cell line (HaCaT) cells and explored miR4298-MAPK ...

the FoxO signaling pathway (hsa04068) and protein processing in the endoplasmic reticulum (hsa04141) were regulated by three or more miRNAs (Table 2). Additionally, pathways related to the hippo ...

AF6 denotes afadin, GAP GTPase-activating protein, GEF guanine exchange factor, MEK mitogen-activated protein kinase ... ERK signaling. Together, these studies uncover novel compensatory pathways ...

This important study investigates the signaling pathways regulating retinal regeneration. Convincing evidence shows that the sphingosine-1-phosphate (S1P) signaling pathway is inhibited following ...

Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.

In flies defective for axonal transport of mitochondria, the authors report the upregulation of one subunit, the beta subunit, of the heterotrimeric eIF2 complex via mass spectroscopy proteome ...

Could nanotechnology improve exercise performance? Evidence from animal studies Lima, M.R. Moreira, B.J. Bertuzzi, R. Lima-Silva, A.E.

Here, our current understanding of the MAP kinase pathway is reviewed, as well as recent advances in the design of novel agents that are able to modulate the activity of these signalling cascades.

Research spanning more than 20 years has led the UPV/EHU's Neurochemistry and Neurodegeneration group under Dr. Rafael Rodríguez-Puertas to discover a promising avenue for the development of new ...