Septerna has a market cap of $750mn and $130mn in cash and ST investments. Discover SEPN's groundbreaking drug discovery ...

Innovative designs of GPCRs with enhanced signaling and stability offer new insights for drug discovery and synthetic biology ...

Recent advancements in understanding GPCR conformational changes and biased signaling have highlighted their critical roles in disease mechanisms. Age-related alterations in GPCR function, dynamics, ...

One significant area of research involves the development of biosensors to study GPCR signaling. A recent study introduced effector membrane translocation biosensors that can monitor the ...

A study demonstrated that nearly all members of the KCTD family interact with Gβγ, influencing the signaling pathways initiated by GPCRs. This interaction is crucial for modulating the adenylyl ...

he created versatile platforms for modulating GPCR signaling. These innovations offer new therapeutic pathways for vascular diseases and GPCR-related pathologies. His team was the first to identify ...

Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions. Their environments—water, lipid membranes, or other condensed phases—are critical to their ...

Activation of the proton-sensing GPCRs by acidosis transduces multiple downstream G protein signaling pathways. Since GPCRs are major drug targets, small molecule modulators of the pH-sensing GPCRs ...