Septerna has a market cap of $750mn and $130mn in cash and ST investments. Discover SEPN's groundbreaking drug discovery ...

With this knowledge, scientists are seeking to better understand the role of GPCRs in islet biology and hormone secretion, and how signaling in the cell through these receptors is disrupted in ...

Innovative designs of GPCRs with enhanced signaling and stability offer new insights for drug discovery and synthetic biology ...

EPFL researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel ...

Get Instant Summarized Text (Gist) A new numbering system for the GAIN domain of adhesion G protein-coupled receptors (GPCRs) has been developed to standardize protein domain comparison, enhancing ...

We also develop phototropin and cryptochrome-based optogenetic tools for regulating G protein signaling independent of GPCRs. These engineered tools allow the acquisition of dynamic molecular pictures ...

Scientists at the Faculty of Medicine have now developed an innovative numbering system for the GAIN domain, a protein domain ...

Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions. Their environments—water, lipid membranes, or other condensed phases—are critical to their ...

The GPCR and plant-like transporter work together ... who leads the Structural Biology of Signaling and Cancer lab at the ...

A thorough examination of modern drugs that target particular receptors and metabolic pathways for glucose and fat metabolism is presented. Recent research has revealed innovative targets and ...