The precise mechanisms by which gabapentin produces its analgesic and antiepileptic actions are unknown. Gabapentin is structurally related to the neurotransmitter gamma-aminobutyric acid (GABA ...
McLean et al. conclude that memantine and gabapentin are useful in the treatment of congenital nystagmus, and call for further studies to determine optimum dosage and duration of effect.
Gabapentin requires disproportionately larger dosage increases to achieve increases in plasma concentrations. The large dosages required for some patients receiving gabapentin could worsen dose ...