People with Li-Fraumeni syndrome often develop cancer as children or young adults, and the germline mutation is associated with a high lifetime risk of cancers, such as breast cancer, bone cancer, ...

A recent study published in Cell reveals that the repeated DNA sequence that leads to Huntington’s disease (HD) expands ...

Scientists are unraveling the mystery of what triggers Huntington's disease, a devastating and fatal hereditary disorder that strikes in the prime of life, causing nerve cells in parts of the ...

Molecular oncology is revolutionizing cancer care by using genetic profiling to tailor personalized treatments, improving ...

Once a mapping population is available, the present method allows a single investigator to identify a causative mutation in only 8 working days of hands-on time. Furthermore, de novo marker ...

Koch and colleagues report that epigenetic clocks mirror age predictions based on the accumulation of somatic mutations and show that somatic mutations at CpG sites coincide with extensive ...

Nearly half of patients with advanced ovarian cancer treated with first-line poly-ADP-ribose polymerase (PARP) inhibitors experienced recurrence in this real-world study, emphasizing the need for ...

2022年7月，一名48岁女性因为持续咳嗽而进行胸部X光检查，发现双侧肺部有多发结节，她接受了胸部计算机断层扫描（CT），结果证实存在多个双侧磨玻璃样混浊，并且肺右下叶基底外侧段存在一个18毫米的实性结节。支气管镜检查显示正常，在支气管冲洗液中检测到 ...

New research shows how cancer develops in children who are predisposed to Wilms' tumor. This could help to predict the development of tumors before ...

In addition to this, we also assessed the prognostic values of these alterations, and specifically in the HER2-positive breast cancer brain metastasis, we observed that the presence of PIK3CA ...

This article explores how broadly neutralizing antibodies are being researched, not only for their potential in the ...