Hypertension is a major global health issue. Aldosterone synthase inhibitors (ASIs) have emerged as a promising therapeutic strategy for blood pressure control. A thorough search of the MEDLINE and ...

Schematic showing how the loss of miR-133a-mediated IP3RII inhibition generates a positive feedback loop to drive the hypertrophic ... myocardin-related transcription factor A; GSK3β, Glycogen ...

Therefore, it is valuable to discover a protein regulating most of EMT-related factors, thus allowing a specific small-molecule inhibitor to potentially target EMT of cancer ... trans-Golgi-network; ...

Correspondence to Dr Pere Ginès, Liver Unit, Hospital Clinic of Barcelona, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona 08036, Spain; ...

Understanding the molecular mechanisms of insulin resistance remains a major medical challenge of the twenty-first century. Over the last half-century, many hypotheses have been proposed to ...

SRC1 was the first cloned steroid receptor co-activator that interacts with steroid hormone receptors to promote transcriptional activation in a hormone-dependent manner. The p160 SRC family ...

More than 80% of sporadic and all hereditary colorectal tumours show a loss of function, owing to truncating mutations in the APC gene. Inhibition of Wnt/β-catenin signalling has therefore been ...

This can include: being rude saying things that aren’t appropriate (for example, that someone is overweight) talking to strangers undressing in public apparent loss of sexual inhibition (for example, ...