Mechanistically, Acod1 suppressed osteoclast differentiation by inhibiting succinate dehydrogenase-dependent production of reactive oxygen species and Hif1α-mediated induction of aerobic glycolysis.

Since osteoclast differentiation and activity are key events in arthritic bone damage, the signals that trigger osteoclastogenesis are potential therapeutic targets. Receptor activator of nuclear ...

2 Department of Rheumatology and Clinical Immunology, Semmelweis University, Budapest, Hungary 4 Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary 5 Heart and ...

Integrated Nucleus of Morphology and Stem Cell Research (NUPCelt), Postgraduate Program in Technologies Applied to Animals of Regional Interest, Federal University of Piauí, Teresina-Pi 64049-550, ...

Cardiovascular and cardiometabolic diseases are leading causes of morbidity and mortality worldwide, driven in part by chronic inflammation. Emerging research suggests that the bone marrow ...

The authors implement a valuable multi-tissue approach to dissect the physiologic consequences of JNK inhibition in parallel with dietary perturbation via sucrose. The conclusions of disrupted liver, ...

There are a significant number of words, phrases and acronyms that appear when talking about race and ethnicity which often change depending on the context of the conversation. Language is ...

As an example, the catabolism of glucose provides a major energy source for the generation of adenosine triphosphate (ATP), a principal energy currency for the maintenance of cellular homeostasis, ...

While recent studies have examined the metabolic requirements of bone formation by osteoblasts, much less is known about the energetic requirements of bone resorption by osteoclasts. The abundance of ...

Brian Beers is a digital editor, writer, Emmy-nominated producer, and content expert with 15+ years of experience writing about corporate finance & accounting, fundamental analysis, and investing ...

Using a model of pressure overload left ventricular hypertrophy (LVH) of the rat heart, in which reduced energy reserve, increased AMPK activity, and increased insulin-independent glucose uptake have ...