while inducing PD-L1 expression to avoid attack by cytotoxic T cells. However, whether and how PD-L1 regulates the DNA damage response and inflammation remains unclear. Here, we show that nuclear ...

The immune checkpoint programmed death receptor-1 (PD-1) and programmed death ligand 1 (PD-L1) are a self-protective measure of the body and have become a focal point in the treatment of non-small ...

Only some lung cancer patients benefit, especially those with PD-L1 protein on their cells, as it responds well to immunotherapy. Clinical trials are exploring new targets beyond PD-L1, potentially ...

Methods: Using flow cytometry, six chordoma cell lines were evaluated for CSC composition. In vitro, cell lines were stained for B7H6, HER2, MICA-B, ULBP1, EGFR, and PD-L1 surface markers. Eighteen ...

Jan. 15, 2025 — While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows.

Jan. 23, 2025 — Researchers have uncovered which genes on the Y chromosome regulate the development of sperm and impact fertility in male mice. This research could help us understand why some ...

PD-L1 combined positive score (CPS): a method used in cancer pathology to assess the level of PD-L1 expression on tumor cells. Progression-free survival (PFS): the length of time during and after ...

nivolumab (Opdivo) in combination with ipilimumab (Yervoy), as first-line treatment for patients with metastatic non-small cell lung cancer whose tumors express PD-L1(≥1%), as determined by an ...