The analysis was performed on independent study sets of HER2-positive and negative/low breast cancers, already analyzed by central immunohistochemistry (IHC) and FISH testing. Phospho-HER2 and ...

结直肠癌（CRC）是全球范围内发病率和死亡率较高的恶性肿瘤之一。HER2 基因扩增在 CRC 中的发生率仅为 3%～5%[1]，但与其预后密切相关，并已成为新的治疗靶点。随着新型 HER2 靶向治疗的出现，针对 HER2 ...

All positive (IHC 3+) and doubtful (IHC 2+) cases were screened by fl uorescence in situ hybridization (FISH). Patients with HER2 gene amplification, normal left ventricular ejection fraction ...

According to Lunit, patients identified by the AI model as having a high proportion of HER2 IHC 3+ tumour cells exhibited better clinical outcomes than those identified through traditional HER2 ...

肝内胆管癌（intrahepatic cholangiocarcinoma, ICC）是一种高度异质性的肿瘤，分子分型是实施ICC 个体化治疗的基础。正确的检测方法对于全面筛选适用靶向药物的患者群体具有重要的临床意义。本共识基于国内外临床实践数据，结合国情，围绕ICC重要靶点进行制定，提出了15 条推荐意见，以期为ICC ...

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涵盖了HER2的检测方法、时机、质控等关键方面，具体如下： 要点1：推荐检测方法 指南推荐采用免疫组化（IHC）和原位杂交法作为主要检测手段，以定量评估HER2蛋白的表达水平和基因扩增状态。当HER2 IHC评分为2+（不确定）时，建议结合原位杂交进行复核。

During a Case-Based Roundtable event, Laura Huppert, MD, reviewed antibody-drug conjugates for a patient with metastatic breast cancer who had progressed on multiple ...

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