The decrease in CD4 cells during HIV infection seems to be driven by immune ... and higher LPS levels were associated with greater activation of CD8 + lymphocytes. CD8 + activation also was ...

In this study, we investigated T cell homeostasis and telomeric DNA damage and repair machineries in cART-controlled HIV patients at risk for inflammaging. We found a significant depletion of CD4 T ...

在格拉斯哥举行的HIV药物治疗会议上，一份病例报告显示， 一名接受具有罕见突变（该突变可阻止病毒进入细胞）的供体干细胞移植以治疗癌症的患者，可能成为 第八例长期病毒缓解的HIV感染者。

Analysis Reveals an Additional Mechanism Behind Statin Therapy's Heart-Related Benefits in People With HIV Dec. 11, 2024 — Investigators who previously found that a daily statin pill helps ...

第一个成功的治愈案例是蒂莫西·雷·布朗，被称为“柏林患者”。2006年，他因急性髓性白血病接受了两次干细胞移植。柏林查理特医院的肿瘤学专家Gero Hütter博士提出使用带有CCR5-delta32突变的供体干细胞，这种突变可以阻止大多数HIV病毒进入细胞。

HIV-1 感染后，在记忆 CD4 T 细胞中形成的潜伏库是实现功能性治愈的主要障碍。尽管抗逆转录病毒疗法（ART）能有效抑制病毒复制，使患者血浆病毒载量检测不到，阻止疾病进展，但一旦停药，病毒就会从潜伏库中重新激活，导致病毒血症复发。“休克 - 杀伤” 策略是目前极具潜力的清除潜伏库的方法，即利用潜伏逆转剂（LRAs）激活潜伏感染细胞中的 HIV-1，再通过细胞毒性淋巴细胞（如 HIV-1 ...

Physicians and their patients report that engagement in an HIV-based community rivals drug effectiveness in the ongoing efforts to curtail an epidemic. Confronting the HIV Epidemic: There's an App ...

Cross-presentation allows DCs to take up antigens from the extracellular environment and present them on MHC class I molecules for CD8 + T-cell activation. Although the exact trafficking patterns ...

If you are a supplier, or another partner you can contact our legacy email address as aidsmap@outlook.com with any queries. We extend our heartfelt thanks to everyone who supported our vision for a ...

The news of a total freeze on “all federal financial assistance” by President Donald Trump on foreign aid and HIV-related initiatives, has raised a global concern, especially among African ...

Interleukins are cytokines produced and secreted mainly by CD3+ and CD4+ T lymphocytes. Interleukins promote development and differentiation of natural killer cells, T and B lymphocytes and ...