Sequence variations in human immunodeficiency virus (HIV)-1 reverse transcriptase (RT) and protease, the molecular targets of anti-retroviral drug therapy, are prime examples of genes in which ...

and the NucliSens™ HIV-1 QT system by bioMerieux Inc (commonly known as the NASBA assay originally owned by Organon Teknika Co.). The Amplicor Monitor™ is a RT-PCR based testing system ...

NRTIs are converted to their active 5'-triphosphate forms inside cells and compete with dNTPs for HIV RT. In addition, as NRTIs lack a 3'-hydroxyl group, they function as a chain terminator and ...

TAM-containing RT demonstrates enhanced excision activity ... Stereogram for the 3D structure of HIV-1 reverse transcriptase in complex with a DNA template-primer and dTTP. The p66 subunit ...