"What is a tumor?" This is the fundamental question to answer if we want to treat cancer effectively. Our vision of cancer ...

A team led by the Cancer Immunogenomics group at the Josep Carreras Leukaemia Research Institute, the Computational Biology group at the Barcelona Supercomputing Center and the Germans Trias i Pujol ...

The tumor microenvironment is acidic due to glycolytic cancer cell metabolism, hypoxia, and deficient blood perfusion. It is proposed that acidosis in the tumor microenvironment is an important stress ...

A team led by the Cancer Immunogenomics group at the Josep Carreras Leukaemia Research Institute, the Computational Biology group at the Barcelona Supercomputing Center and the Germans Trias i Pujol ...

This strategy may provide a new approach for treating HCC. Secondly, AFP is also involved in the interaction between liver cancer cells and the immune microenvironment (29). AFP overexpression can ...

according to its hallmark’s expression instead of cell-type. In this way, they could see how malignant cells specialised in growing the tumour, while non-cancer cells surrounding it – called the ...

The hallmarks of cancer are features that ... cells surrounding it – called the tumor microenvironment – contributed with the suppression of the immune system or preventing the efficient ...

CITE-Seq (cellular indexing of transcriptomes and epitopes, a type of single-cell RNA sequencing that utilizes antibody tagging of each cell type before sequencing) demonstrated significantly higher ...