As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

Histologic assessment of a liver biopsy specimen remains the gold standard for quantifying fibrosis, with increasing interest in the use of noninvasive markers to allow more frequent sampling and ...

14 Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA The field of pancreatic stellate cell (PSC ...

Additionally, QZRG granules suppressed the proliferation of activated hepatic stellate cells. Conclusion: Our findings suggest that QZRG granules may exert anti-fibrotic effects by downregulating ...

Design Levels of BMP-9 and its receptors were analysed in primary liver cells. Direct effects of BMP-9 on hepatic stellate cells (HSCs) and hepatocytes were studied in vitro, and the role of BMP-9 was ...

The liver is largely comprised of hepatocytes, but Kupffer cells, endothelial cells and hepatic stellate cells are also present. A perfusion-independent method to isolate ultrapure liver ...

Cellular senescence, where cells permanently stop dividing, plays a complex role in liver health. In a recent review article, ...

As a metabolic center, the liver prevents inappropriate immune responses to abundant dietary antigens within the liver that could result in liver injury. This self-preservation mechanism can however ...

In 2023, the global hepatic markers market is expected to be worth USD 2.3 billion. The market is expected to reach USD 4.2 billion by 2033, expanding at a 6.2% CAGR throughout the forecast period.

近日，中国科学院广州生物医药与健康研究院和海军军医大学附属东方肝胆外科医院合作在Hepatology发表了题为Lhx2 specifically expressed in hepatic stellate cells promotes liver regeneration and inhibits liver fibrosis的研究论文 近日，中国科学院广州生物医药与健康研究院和海军军医 ...

This suggests these cells may be useful as new therapeutic targets for various liver conditions. The work appears in the journal Immunity. Macrophages are specialized immune cells located in every ...