Aberrant epigenetic modifications also contribute to the persistent activation of SSc fibroblasts. We investigated whether increased Wnt signalling and epigenetic changes in SSc are causally linked ...
本文由论文原创团队投稿点击查看原文引用本文Bai C, Xiao P, Chen Y, Chu F, Jiao Y, Fan J, et al. GPX4 Promoter Hypermethylation Induced by ...
Background: The efficacy of current therapeutic schedule is limited owing to fibroproliferative tumor microenvironment (TME) of cholangiocarcinoma, compelling a search for new therapeutic targets.
Epigenetic alterations have emerged as critical factors in the pathogenesis of brain cancer, particularly gliomas. This article explores the impact of organochlorine pesticides (OCPs) on the ...
Here the authors show D-2-HG leads to genome-wide DNA hypermethylation and loss of CTCF coverage, which impairs the assembly of the homologous recombination DNA repair machinery and associated ...
It is still controversial whether IM itself is a precancerous or paracancerous lesion. With crypt isolation, IM cells had a unique DNA methylation profile, especially extensive hypermethylation in ...
These hypoxia-induced pro-fibrotic changes were associated with global DNA hypermethylation, and increased expression of DNA methyltransferase (DNMT) enzymes DNMT1 and DNMT3B. DNMT3B significantly ...
With the strong associations established in epidemiologic studies and a dearth of evidence on the actual mechanisms by which ...
Validation of the seven CpGs with RRBS data of cfDNA methylation was further conducted and supported the reliability of the 7-CpGs methylation panel. Finally, a hypermethylation CpG locus (cg02261780) ...
DURECT Corporation (Nasdaq: DRRX) today announced that James E. Brown, President and Chief Executive Officer, will present at ...
Background Biological ageing is one of the principal risk factors for neurodegenerative diseases. It is becoming increasingly clear that acceleration of DNA methylation age, as measured by the ...