and postprandial hyperglycemia can all alter gene expression and cell signaling in vascular endothelium, cause vascular insulin resistance, and change the release of endothelium-derived factors.

A protein encoded by the Klotho gene can circulate in the blood and ... Heterozygous or complete deletion of the insulin receptor in several tissues, including liver, skeletal muscle, neurons ...

Figure 1. Structures of the insulin/insulin-like growth factor (IGF) system. Insulin, IGF1, and IGF2 and their relatively high-affinity receptors, insulin receptor, IGF1 receptor, and IGF2 receptor, ...

A study on GLP1RA medications found that behavioral side effects likely do not result from direct action on GLP1R.

The IGF family (table 2) consists of two ligands, IGF1 and IGF2, two cell-membrane receptors, IGF1R (which can form heterodimers with the insulin receptor) and IGF2R (which has two mannose-6-phosphate ...

Within a week insulin gene expression dropped, suggesting that insulin-producing cells were beginning to die. 2 weeks later, expression of an insulin receptor gene (insulin growth factor 2) had also ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Impaired insulin receptor signaling is ...

A RECENT population-based analysis has highlighted potential behavioural side effects associated with Glucagon-like peptide 1 ...

A U.K. study has uncovered distinctive genetic drivers of type 2 diabetes in South Asians that lead to faster development of complications, the need for earlier insulin replacement therapy and a ...

Glucagon-like peptide 1 receptor agonists (GLP1RA)—medications for type 2 diabetes and obesity that have recently been making ...

Glucagon-like peptide 1 receptor agonists (GLP1RA)—medications for type 2 diabetes and obesity that have recently been making headlines due to a rise in popularity as weight loss agents—have been ...

Glucagon-like peptide 1 receptor agonists (GLP1RA)-medications for type 2 diabetes and obesity that have recently been making headlines due to a rise in popularity as weight loss agents-have been ...