A groundbreaking discovery has unveiled a promising avenue in diabetes research. Scientists have identified a novel enzyme, ...

Rosiglitazone acts as a full agonist of PPARγ, a nuclear receptor that ... and adiponectin (an insulin-sensitizing adipokine). Not only are the agonist and phosphorylation effects separable ...

Polycystic ovary syndrome (PCOS) can put you at risk for insulin resistance. Watch for symptoms of insulin resistance that are common for females with PCOS. These include cravings and frequent ...

Protein phosphorylation is a covalent post-translational ... This is both because of their relevance to growth factor–receptor signaling and the availability of good antiphosphotyrosine ...

Surprisingly, cellular senescence caused an overall increase in insulin signaling in hepatocytes, with increased insulin-stimulated phosphorylation of IR, Akt, and MAPK. Together, these data indicate ...

From top to bottom: The prophase arrest is maintained by high PKA activity due to the constitutively expressed GPR185 receptor. The exocytic pathway is active while the endocytic pathway is ...

Diabetes and obesity are two metabolic diseases characterized by insulin resistance and a low-grade inflammation. Seeking an inflammatory factor causative of the onset of insulin resistance ...

Peptides have emerged as a focal point in molecular and biological research, providing a promising avenue for understanding ...

A single-center pilot study at the Veterans Affairs Hospital/University of Washington in Seattle reported improved verbal memory retention and attention after a three-week test of 20 international ...

Background Obesity is associated with accumulation of macrophages in white adipose tissue (WAT), which contribute to the development of insulin resistance. Germ-free (GF) mice have reduced adiposity ...

From Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville Campus, Victoria, Australia (R.H.R.) Division of Endocrinology and Metabolism (E.D.A.), ...

Diabetes mellitus is a metabolic disease that causes high blood sugar. Your body either doesn’t make enough insulin or can’t effectively use the insulin it makes. The hormone insulin moves ...