Here we discuss diacylglycerol-mediated insulin resistance as an alternative and unifying hypothesis to explain the most common forms of insulin resistance associated with obesity and type 2 ...

(3) DDX3X can be phosphorylated by Akt, and Akt can increase the phosphorylation of NLRP3. (4) PI3K/Akt/mTOR/NF-κB signaling pathway can also regulate pyroptosis mediated by NLRP3 inflammasome. (5) ...

We show that inactivation of Ezrin is crucial to neutralize EGF-stimulated EGFR endosomal sorting and signaling from the plasma membrane with a reduction of AKT-mediated phosphorylation of TSC complex ...

FIGURE 1. AKT structure. The three AKT isoforms (AKT1/2/3) are kinases sharing a common structure, which consists of an N-terminus pleckstrin homology (PH) domain, a large central kinase domain and a ...

When you have diabetes, insulin is vital to help keep your blood sugar levels in check. If you have type 1 diabetes, you must inject insulin daily. Those with type 2 diabetes may also require ...

Insulin overdose symptoms can include confusion, fatigue, irritability, shaking, and other signs of low blood sugar (hypoglycemia). Insulin dosing is a multistep process that often requires careful ...

Insulin allows cells to absorb and use glucose. In people with insulin resistance, the cells are unable to use insulin effectively. Insulin resistance occurs when cells in the body do not respond ...

Many drugs, including insulin, essentially became free. But the American Rescue Plan made a major change that hit drug companies with even larger penalties for raising prices. In January 2024 ...