Tyrosine (Tyr) phosphorylation of p27 by Abl and Src family kinases reduces p27–CDK2 inhibition and transforms p27 from inhibitor to substrate of cyclin–CDK2 complexes. p27 phosphorylation at ...

In recent years, cancer immunotherapy has made remarkable achievements. Immune checkpoint inhibitors (ICIs) have been used successfully in several types of cancer in the past decade. However, expanded ...

Moreover, JAK inhibitors such as tofacitinib, peficitinib, upadacitinib and decucravacitinib are also good options for IBD treatment. Therefore, various antibodies blocking the activity of ...

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Exposures include: HBsAg-positive group: Anthracycline derivatives, anti-TNF agents, anti-IL-6 agents, B-cell-depleting agents, CAR T-cell therapy, cytokine/integrin inhibitors, transcatheter ...

Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China ...

A separate retrospective analysis of a larger cohort of 1091 patients with advanced NSCLC who were progression-free after at least 2 years of immune checkpoint inhibitor therapy similarly did not find ...

Angiogenesis inhibitors can be divided in 2 main groups according to their mechanism of action [3]: those that act directly on microvascular endothelial cells recruited by the tumor, such as ...

Antiangiogenesis, heralded a while ago as the "magic bullet" to stop cancer growth, has lately entered a reconsideration phase. Results obtained in phase 1 through 3 clinical trials with different ...

Jiangsu Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China Jiangsu Key Laboratory of Drug Design and ...