1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts. 2Department of Biological Engineering, Massachusetts Institute of Technology, ...

Importantly, tumor cells are able to switch their integrin expression and the type ... targeting of the various elements of the tumor microenvironment or targeting signaling pathways activated ...

The significant role of tumor microenvironment (TME) in the initiation, development, and progression of OSCC has been widely recognized. Various cells in TME, including tumor-associated macrophages ...

Surgical resection remains the only curative option as systemic therapies offer limited benefit. Poor response to chemotherapy and immunotherapy is due, in part, to the dense stroma and heterogeneous ...

ITGAX (Integrin alpha X) is closely associated with immune cells ... Additionally, its strong association with immune regulation suggests a dual role in modulating the tumor microenvironment. Further ...

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Integrins are very attractive therapeutic targets in oncology. The anti-tumor mechanisms of integrin-targeting drugs have been validated both in vitroand in vivo. Integrin-targeting drugs are ...

Imaging its expression would allow the efficacy of anti-angiogenic drugs in patients to be predicted. However, most studies used animal models with integrin αvβ3 expression on the tumor cell surface.