Interestingly, these processes are all sensitive to the concentration of oxygen present in the microenvironment. Rapidly proliferating cells cause the NSCLC tumor to extend beyond the oxygen ...

Besides an extensive range of genetic and epigenetic alterations, components of the tumor microenvironment tend to exert a significant impact on tumor progression. The so-called tumor ...

Explore the role of the extracellular matrix (ECM) in prostate cancer progression and discover natural therapies, including ...

Integrins are very attractive therapeutic targets in oncology. The anti-tumor mechanisms of integrin-targeting drugs have been validated both in vitroand in vivo. Integrin-targeting drugs are ...

FN can interact with the integrin receptor ITGA5 on the cancer cells ... We also evaluated changes in the tumor immune microenvironment and found that our treatment increased the percentage of CD8 + T ...

An immuno-oncology targeting panel accurately characterized tumor-resident immune cells and located pathologically and clinically relevant tumor microenvironment features. Cancer development and ...

Engineered immune cells called CAR-T cells are used in the treatment of cancer. Researchers from Uppsala University have now ...

The frontrunner of Vincerx’s bioconjugate programs, VIP236, is an SMDC engineered to bind an α v ß 3 integrin adhesion ... overexpressed in the tumor microenvironment of many malignant tumors.

Dr. Won Jin Ho presented a talk as part of the Immunology Neighborhood Seminar on “Overcoming the tumor immune ...

Recent research has focused on understanding the multifaceted roles of legumain in cancer, particularly its involvement in tumor growth, metastasis, and the tumor microenvironment. Recent studies ...