Besides an extensive range of genetic and epigenetic alterations, components of the tumor microenvironment tend to exert a significant impact on tumor progression. The so-called tumor ...

An immuno-oncology targeting panel accurately characterized tumor-resident immune cells and located pathologically and clinically relevant tumor microenvironment features. Cancer development and ...

The frontrunner of Vincerx’s bioconjugate programs, VIP236, is an SMDC engineered to bind an α v ß 3 integrin adhesion ... overexpressed in the tumor microenvironment of many malignant tumors.

Integrins are very attractive therapeutic targets in oncology. The anti-tumor mechanisms of integrin-targeting drugs have been validated both in vitroand in vivo. Integrin-targeting drugs are ...