Overall, the results demonstrated that mitochondrially targeted iron chelators mitoDFX and mitoDFO are capable of inducing NDRG1 mRNA and protein levels in breast cancer cells, while only low levels ...

On the basis of median [interquartile range] R2* values in MRI (Figure 2 E), iron levels in the SN fell greater in the AT group (from 4.5 [4.2–4.9] at baseline to 3.9 [3.8–4.1] after 6 months ...

Patients on dopaminergic agonists (n, mean daily L-dopa equivalent in mg) 18 (243) 18 (220) 4 (225) 13 (250) Patients on L-dopa and agonists (n) 7 7 2 5 Cognition and behavior: MDS-UPDRS part I ...

T2* MRI is particularly useful for evaluating cardiac iron overload and guiding chelation therapy adjustments. Liver iron concentration (LIC) measurement through R2 and R2* MRI techniques provides ...

This is because mammals, such as humans, cannot secrete excess iron in a controlled manner (Camaschella et al., 2020). To treat these conditions, iron chelation therapy has long been the gold standard ...

Global Thalassemia Market Global Thalassemia Market Dublin, Jan. 31, 2025 (GLOBE NEWSWIRE) -- The "Thalassemia Market by ...

Non-transfusion-dependent thalassemia encompasses three clinically distinct forms -- beta-thalassaemia intermedia, hemoglobin E/beta-thalassaemia (mild and moderate forms), and al ...

Copper chelation shows promising results in certain lung cancers where cells have two related phenomena: a heightened transcription factor responding to oxidative stress and a diminished level of ...

The Chang Lab at Princeton Chemistry continues in its mission to elucidate the role of metal nutrients in human biology: last year, iron ... modality in which copper chelation shows promising ...

Discover how copper impacts lung cancer growth and how copper chelation therapy could be a promising treatment.

If you have been diagnosed with iron deficiency with or without anemia, it may seem like an easy fix. "I'll just take some iron tabs, and everything will be fine." Although this is true for many ...