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生物通
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CDCA7增强STAT3转录活性,调节有氧糖酵解,促进胰腺癌进展和吉西他滨 ...
CDCA7 属于细胞周期调节蛋白家族,作为致癌基因,在多种肿瘤中高表达,与不良预后相关,且参与肿瘤细胞的增殖、侵袭和转移过程,但它在胰腺癌中的具体作用尚不清楚。近年来,代谢重编程在胰腺癌耐药发展中的作用受到广泛关注,其中糖酵解代谢重编程是导致化疗耐药的关键因素之一。信号转导和转录激活因子 3(STAT3)是 STAT ...
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