Familial hypercholesterolemia results from gene mutations approximately halving the number of functional LDL receptors in heterozygotes and a greater lack in homozygotes. Reduced receptor-mediated ...

The biological fates of the key initiator of Alzheimer’s disease (AD), the amyloid precursor protein (APP), and a family of lipoprotein receptors, the low-density lipoprotein (LDL) receptor-related ...

In 1985, the Nobel Prize in Physiology or Medicine was awarded to Michael Brown and Joseph Goldstein for identifying the receptor that clears LDL particles from the bloodstream. High blood levels ...

Introduction: Post-stroke fatigue (PSF) is a common and debilitating consequence of cerebrovascular accidents, potentially stemming from central and peripheral mechanisms. Recent studies have linked ...

ABSTRACT: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of the proprotein convertase (PCs) family, which facilitates the degradation of low-density lipoprotein receptors (LDL-R) ...

Figure 1 Cholesterol and lipid microenvironment regulate HIF-1α. Low density lipoproteins (LDL) are taken up into the cells via endocytosis of the LDL receptor (LDLR). Fatty acids released by the ...

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located at the extracellular end of the nicotinic acetylcholine receptor (AChR) α subunit, and investigated its clinical relevance in myasthenia gravis (MG). Methods In this retrospective cohort study ...

Insulin binding induces structural changes within the receptor. These changes trigger a biochemical chain of events inside the cell, (signal transduction) that finally leads to the activation of the ...

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Recent research has shown that even when LDL cholesterol has been reduced to optimal levels ... In the same announcement, Marea shared its second pipeline candidate, an anti-growth hormone receptor ...