Homozygous familial hypercholesterolaemia affects approximately 30 000 individuals worldwide.1,2 Patients have untreated high ...

As a consequence, they lower the hepatic cholesterol pool and promote the expression of LDL receptors in the liver. Bile acid sequestrants are the safest lipid-lowering drugs but have frequent ...

Also, we decipher the role of antibodies in the attachment of the virus to receptors, internalization, and uncoating process, providing insight into virus neutralization mechanisms. Moreover, ...

Recent research has shown that even when LDL cholesterol has been reduced to optimal levels ... In the same announcement, Marea shared its second pipeline candidate, an anti-growth hormone receptor ...

Faculty of Medical Technology, Prince of Songkla University, Songkhla 90110, Thailand Division of Biological Science, Faculty of Science, Prince of Songkla University, Songkhla 90110, Thailand ...

Inhibitors of IL-6 action can target either the IL-6 ligand itself or the IL-6 receptor. Tocilizumab is a humanized monoclonal antibody targeting the IL-6 receptor that was approved by the FDA in 2010 ...

In contrast, eNOS is not activated by purified forms of the major HDL apolipoproteins ApoA-I and ApoA-II or by low-density lipoprotein ... reveal that scavenger receptor-BI (SR-BI) mediates ...

To study the function of the LDL receptor, LDL particles fluorescently labeled with pHRodo-Red (0.5 mg/ml ... To determine LDLR plasma membrane localization, monoclonal anti-hLDLR APC-conjugated Mouse ...

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