Phthalates are a group of chemical compounds commonly used as plasticizers to enhance the flexibility and durability of plastics. However, their widespread use has raised significant health ...
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The sterol regulatory element-binding transcription factor 1 (SREBP-1), PPAR-γ coactivator-1α (PGC-1α), sirtuin 1 (SIRT1), fatty acid synthase (FASN), farnesyl-diphosphate farnesyltransferase 1 ...
Expert Rev Cardiovasc Ther. 2008;6(3):391-409. Phosphatidic acid phosphatase/phosphohydrolase (PAP) is an enzyme that catalyzes the conversion of phosphatidic acid to ...
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Mediator kinase inhibition also activates SREBP, which likely results from rapid suppression of p53 (Moon et al. 2019). Metabolic changes include increased levels of PPAR and LXR ligands, which tracks ...
Apolipoprotein E (ApoE) is a key genetic risk factor in the complex landscape of Alzheimer’s disease (AD), especially in its late-onset sporadic form. Genetic variation in the ApoE gene is a ...
Investigating whether other SREBP family members, such as SREBP1, similarly impact HBV replication could also enhance our understanding of lipid metabolism’s role in HBV pathogenesis. Given HBx’s ...
Clin Lipidology. 2014;9(1):101-118. TAUSSIG: a multicenter, open-label study to assess the long-term safety, tolerability, and efficacy of AMG145 on LDL-C in subjects with severe familial ...