We discuss the challenges such as immunosuppressive microenvironment, tumor heterogeneity, and physical barriers that limit CAR-T efficacy. Emerging strategies, such as logic-gated and dual-targeting ...

When a child develops a brain tumor, early diagnosis is essential. Alan Cohen, M.D., director of pediatric neurosurgery at Johns Hopkins Children’s Center, shares the most common signs and symptoms ...

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The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and ...

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Radiation therapy, as well as having a close relative who has had a brain tumor, can also slightly increase a person's risk of developing the disease. Treatment for brain tumors depends on the ...

We further found that neurons with accumulation of phospho-tau immunostaining contained rG4s, that rG4 structure can drive tau aggregation, and that rG4 staining density depended on APOE genotype in ...

Effect size analysis indicated that 5FU had the most substantial impact, followed by the combination treatment, while DOX showed a moderate effect in reducing tumor growth (Supplementary Table S1).

Using domain-specific computational methods, we evaluated the accuracy of virtual H&E staining for histologic subtyping and virtual mIF for cell segmentation–based measurements, including clinically ...