In turn, that weight gain and excess fat cells can contribute to leptin resistance. Leptin receptor deficiency is a rare genetic condition causing a person to be born with few leptin receptors.

In humans, many leptin deficiency syndromes are responsive to ... who have normal genes for leptin and its receptor, are leptin resistant. Despite extensive efforts in many laboratories, it ...

leptin-deficient ob/ob mice and intestine-specific leptin receptor isoform B-deficient mice. These data demonstrate that gastric leptin is upregulated in obese individuals. Results from high-fat ...

"The findings support the known role of leptin variations in late-life dementia risk by relating its deficiency with changes ... its soluble leptin receptor and their ratio, known as the free ...