One theory of leptin resistance is that the brain receptors become desensitized to leptin when levels are constantly high. This is similar to how insulin resistance occurs, which is when the body ...

Their hypothalamic expression levels are elevated in obesity and thus might contribute to the development of leptin resistance (166–168). Recently, Ottaway et al. reported that central or peripheral ...

In humans, many leptin deficiency syndromes are responsive to leptin replacement therapy. As leptin is involved in numerous pathways, the effects of too little leptin are widespread (including ...

Deficiencies in—or resistance to—some of these factors have already been identified. Friedman estimates that 10–15% of severe human obesity results from single-gene defects at various points in this ...

Leptin is a fat hormone which acts in maintaining energy balance. However, leptin levels are high in obese subjects indicating resistance to the actions of leptin. High leptin levels have been ...

However, there may be circumstances where a person develops a resistance to leptin, weakening the body’s reactivity to the hormone. This unfavourable circumstance could result in overeating ...