One theory of leptin resistance is that the brain receptors become desensitized to leptin when levels are constantly high. This is similar to how insulin resistance occurs, which is when the body ...

In humans, many leptin deficiency syndromes are responsive to leptin replacement therapy. As leptin is involved in numerous pathways, the effects of too little leptin are widespread (including ...

However, there may be circumstances where a person develops a resistance to leptin, weakening the body’s reactivity to the hormone. This unfavourable circumstance could result in overeating ...