However, many people with obesity have leptin resistance, meaning their brains don’t process the hormone effectively, so they frequently feel hungry. Over time, that can lead to obesity.

But in some individuals with obesity, this signaling system seems to malfunction—a condition known as leptin resistance, where high levels of leptin fail to curb hunger. Why this resistance ...

A diabetes drug may beat costly shots for patients with a rare genetic condition, according to a Rutgers Health study.

However, leptin therapy is not a panacea for curing obesity, because most obese humans, who have normal genes for leptin and its receptor, are leptin resistant. Despite extensive efforts in many ...

These changes result in dynamic alteration of adipokine production that reflect the severity of obesity, chronic inflammation with the infiltration of macrophages, leptin resistance, and altered ...

Discover how tirzepatide, a diabetes drug, offers hope for congenital generalized lipodystrophy (CGL) treatment, potentially ...

Michael W. Schwartz UW Medicine Diabetes Institute, explains how the brain can be targeted to treat obesity and diabetes ...

A weekly injection of diabetes medication could replace painful daily hormone shots for patients with a rare form of lipodystrophy.

Poles are consuming increasing amounts of sugar, which is contributing to widespread health issues, including obesity and ...