Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

Ligand Pharmaceuticals Incorporated, a biopharmaceutical company, engages in the development and licensing of biopharmaceutical assets worldwide. Its commercial programs include Kyprolis and ...

These tests are typically binding protein dependent to some extent and should more appropriately be called "Free Hormone Estimate" tests, abbreviated FT4E and FT3E. In general, Free Hormone ...

Researchers now offer a simplified method they call ProteinReDiff that uses artificial intelligence to speed the redesign of ligand-binding proteins. In biology, the binding of cellular proteins ...

Strickland Metals is gearing up for a blockbuster start to 2025, with a flood of key assay results expected to start pouring in next week from its Shanac and Gradina deposits at the company’s flagship ...

Substrate and inhibitor binding are distinguished by major TM rearrangements and their ligand binding chemistry, with TM4 playing a central role in all conformational transitions. Furthermore, our ...

Department of Chemistry, Illinois Institute of Technology, Chicago, Illinois 60616, United States ...

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today announced a five-year strategic alliance to accelerate the clinical evaluation and development of Myriad’s molecular residual disease (MRD) assay. This strategic alliance brings together ...