Qualifying patients (n=51) were allocated to placebo, 25 or 100 mg losartan, or 20 mg enalapril. Blood pressure, plasma drug concentrations, and renin-angiotensin-aldosterone system mediators were ...

and losartan 50 mg force-titrated to 100 mg (n=115) once daily, as assessed by clinic and ambulatory blood pressure. They found that candesartan cilexetil 16 mg reduced ambulatory BP to a ...

During both 18-week periods, patients received each of the following for 6 weeks, in random order: placebo; losartan (100 mg/day); and losartan (100 mg/day) plus hydrochlorothiazide (25 mg/day).

Once-daily administration of losartan is possible because the drug's effects are extended by ... The dosage can be increased to a maximum of 100 mg daily. Doses exceeding 100 mg have not been ...