Figure 2. The mechanism of action of CAR-Ms includes TAA-induced phagocytosis, secretion of proinflammatory cytokines, activation of T cells, remodeling of the TME, and recruitment of other immune ...

M2c macrophages are triggered by IL-10, TGF-β, or glucocorticoids and exert phagocytosis and clearance of apoptotic cells, immunosuppression, stimulation of angiogenesis, and development of tissue ...

The Damon Runyon Cancer Research Foundation has announced eight recipients of the 2025 Damon Runyon-Rachleff Innovation Award, established to support high-risk, high-reward ideas with the potential to ...

Division of Physiological Chemistry and Metabolism, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-0011, Japan Laboratory of Metabolomics, RIKEN Center for Integrative ...

Our approach relied on the well-known ability of macrophages to engulf oxidatively modified lipoproteins and apoptotic cell membranes ... in macrophages. Phagocytosis of oxPL in human macrophages ...

The $4.9 billion acquisition of Forty Seven by Gilead is an example of the explosive excitement and investment into macrophage-directed therapies, utilizing CD47 checkpoint blockades ...

Jan. 23, 2025 — There's a downside to being a powerful alpha male -- at least if you're a baboon. Studies show that despite their high rank, the No. 1 males in baboon society are also some of ...

This study aimed to link these observations to define a role for macrophages in the pathology of human CD. Methods Human peripheral blood CD14 cells were polarised in vitro into M1 and M2 macrophages.

kuleuven.be Intestinal resident macrophages are at the front line of host defence at the mucosal barrier within the gastrointestinal tract and have long been known to play a crucial role in the ...