Human monocyte-derived macrophages (hMDM) were differentiated from CD14 + monocytes of healthy controls, patients with SSc, RA, PsA, and axSpA. In some experiments hMDMs pretreated with 0.1 μM ...

Macrophages are implicated in atherosclerosis, inflammation, and ageing pathologies. Their dysfunction with age includes decreased phagocytosis, which may contribute to the increased development of ...

Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical ...

Unanue, E. R., Nature, 218, 36 (1968).

In particular, the adipose tissue macrophages (ATMs) are important in the pathogenesis of obesity ... There are several markers that confirm the exosome’s structural organization, including CD63, CD81 ...

Immunohistochemical localization of oxPL contrast agent within atherosclerotic plaque confirmed selective accumulation in macrophages. Phagocytosis of oxPL in human macrophages involves α v β 3 ...

The effects of a Btk-specific inhibitor, RN486, on gene expression in human macrophages and RA synovial tissue explants (n=8) were assessed by qPCR, ELISA and single-plex assays. Results Btk was ...

Using lineage tracing, we find that tissue-resident red pulp macrophages (RPM), initially depleted by BCG exposure ... MARS-seq pipeline 57 was used for demultiplexing, alignment to the genome (mm9), ...

Jan. 15, 2025 — A cutting-edge molecular approach provides a detailed picture of the biological pathways associated with childhood obesity and metabolic dysfunction, and identifies environmental ...