The Damon Runyon Cancer Research Foundation has announced eight recipients of the 2025 Damon Runyon-Rachleff Innovation Award, established to support high-risk, high-reward ideas with the potential to ...

This study unveiled the role of Lrrk2 gene in regulating macrophage polarization and immune response. This finding provides ...

A massive trans-ancestry genome-wide association study (GWAS) looked at the genetic makeup of 688,808 individuals with depression and 4,364,225 people in the control group and identified, in total ...

This complex process, known as gene expression, determines which proteins we make and whether we make them in the correct amounts, crucial work given that proteins play a role in virtually every a ...

In a phagocytosis assay using Aβ as a substrate, macrophages isolated after the treatment engulfed less Aβ than did ... Abnormal TSPO values in a child’s blood panel, for instance, could be a tip-off ...

The same is now possible in gene editing. Rather than employ separate tools for editing genes and regulating their expression, these distinct goals can now be combined into a single tool that can ...

Using lineage tracing, we find that tissue-resident red pulp macrophages (RPM), initially depleted by BCG exposure ... MARS-seq pipeline 57 was used for demultiplexing, alignment to the genome (mm9), ...

Some genes are beneficial and enhance longevity. For example, the gene that helps a person metabolize cholesterol would reduce a person's risk of heart disease. Some gene mutations are inherited.

Pharmacologic or genetic interventions that inhibit oxidative phosphorylation do not augment pro-inflammatory gene expression or cytokine release. Peritoneal macrophages activated in vivo do not have ...

Immunohistochemical localization of oxPL contrast agent within atherosclerotic plaque confirmed selective accumulation in macrophages. Phagocytosis of oxPL in human macrophages involves α v β 3 ...