米托蒽醌作为 Usp11 的抑制剂，给予野生型小鼠米托蒽醌处理后进行 TBI，结果显示米托蒽醌干预使 Usp11+/+ 小鼠脾脏边缘区变窄，减轻了电离辐射后 MZ B 细胞数量的减少。流式细胞术分析表明，米托蒽醌处理后，Usp11+/+ 小鼠受 TBI 后 MZ B 细胞的总百分比显著高于 PBS 处理组，且血清 IgM 水平变化表明米托蒽醌干预减少了抗体类型的转变。这说明靶向 Usp11 ...

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