M2型肿瘤相关巨噬细胞与肿瘤细胞分化程度显著相关, 是乳腺癌、胶质母细胞瘤和胃癌等恶性肿瘤增殖和转移的重要标志物. CD206是M2型巨噬细胞特异性的检测靶点, Teesalu等通过噬菌体展示技术筛选了靶向CD206的多肽CSPGAKVRC (UNO). FAM修饰的UNO与CD206抗体共定位成像小鼠 ...

Inflammatory macrophages are defined by higher expression of antigen-presenting and co-stimulatory molecules including CD80/CD86, CD40, MHCII, and secretion of inflammatory cytokines, whereas ...

This paper evaluates a recent work that utilizes one such molecule, the human CD206, transgenically incorporated into mouse, in order to establish its role in immune response. Such a study ...

Macrophage infiltration into adipose tissue is a key pathological factor inducing adipose tissue dysfunction and contributing to obesity-induced inflammation and metabolic disorders. In this review, ...

Srinivas V. Kaveri, DVM, PhD, Unite 872, Institut National de la Sante et de la Recherche Medicale, F-75006 Paris, France and Centre de Recherche des Cordeliers, Equipe 16 Immunopathologie et ...

Correspondence to Professor Fuming Qiu, Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; qiufuming{at}zju.edu.cn; ...

Correspondence to Professor Guy Boeckxstaens, Translational Research in Gastrointestinal Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing (Chrometa), KU Leuven, Leuven, ...