Fatal neurodegenerative disease in kids also affects the bowel—gene therapy may help
Researchers at Washington University School of Medicine in St. Louis have described the neurodegeneration that occurs in the ...
Hosted on MSN11mon
Researchers discover a promising compound to treat neuropathic pain
We and others have shown that σ2R/TMEM97 ligands alleviate mechanical hypersensitivity in mouse neuropathic pain models with a time course wherein maximal antinociceptive effect is approximately ...
Morphine tolerance found to result from Tiam1-mediated maladaptive plasticity in spinal neurons
Using a mouse model of neuropathic pain, Li and Tolias reported last year in the journal Neuron that Tiam1 acts to coordinate ...
FierceBiotech13d
Drug candidate restores myelin and leg mobility in multiple sclerosis mouse model
An investigational drug for multiple sclerosis from Io Therapeutics has restored leg mobility and myelin nerve coatings in ...
Nature3y
The Use of Animal Models in Studying Genetic Disease: Transgenesis and Induced Mutation
You are more like a mouse than you might think! Today, scientists are creating models of human genetic disease using mice, flies, worms, and other animals. But what do these models reveal about us?
Multiple Sclerosis News Today7d
IRX4204 promotes myelin repair, improves gait in MS mouse model
Scientists say IRX4204 given to mice with evident symptoms showed potential "as a remyelinating and neurorestorative ...
Nature5y
Activation of the TRPM8 channel can generate analgesia in chronic neuropathic pain
In a rat model of neuropathic pain, mild cooling of the skin or peripheral or central application of icilin produced marked analgesic effects, inhibiting sensitization of dorsal-horn neurons and ...
MassDevice16d
Autonomix secures U.S. patent for cancer-treating tech
Autonomix received a patent from the U.S. Patent and Trademark Office (USPTO) for its catheter-based cancer tumor treating ...