High-throughput miRNA sequencing of serum samples was performed to profile differentially-expressed miRNAs (dif-miRNAs) and preliminarily screen candidate miRNAs. The diagnostic power of the candidate ...

2018). The advent of next-generation sequencing technologies has paved the way to cost-effective and highly efficient methods to identify miRNA–mRNA regulatory networks related to complex traits in ...

This review will briefly describe epigenetic mechanisms before introducing important aspects of miRNA regulation ... important roles in modifying the sequence, structure, or expression of mRNAs ...

the key feature of the mechanism of action of miRNAs is that a single miRNA can regulate the expression of several genes, depending on the specificity of the target sequence; conversely, individual ...

The origin of their recognition comes from a pair of studies published in the journal Cell way back in 1993, which demonstrated for the first time that microRNA was involved in gene regulation in ...

Researchers are enhancing the best features of AAV capsids and overcoming their limitations to accelerate gene-based therapies.

Abstract Research of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia (FM), two acquired chronic illnesses affecting mainly females, has failed to ascertain their frequent ...

Regulus Therapeutics Inc. , a biopharmaceutical company focused on the discovery and development of innovative medicines targeting microRNAs (the "Company" or "Regulus"), today announced that members ...