Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The carboxyl terminus of Hsc70-interacting ...

Mitochondria are now known to not only generate energy but also produce essential cellular materials, adapting uniquely to stress, which sheds light on cancer survival tactics and aging processes.

Masroor Ahmad Paddar and colleagues reveal noncanonical roles of ATG5 and membrane ATG8ylation in regulating retromer assembly and function. They identify ATG5's unique non-autophagic role and show ...

This important work identifies a non-autophagic role for ATG5 in lysosomal repair and the trafficking of the glucose transporter GLUT1 to the cell surface, mediated through the retromer complex. The ...

In summary, ER and mitochondria contact surface increases in response to lack of nutrients. This adaptive increase in contact sites is impaired under obesogenic conditions. However, it is still ...

Most of us remember two things from high school biology: that mitochondria are the powerhouses of cells and that we inherit stable sets of chromosomes from our two parents. Both truisms are only ...

forming FIP200 puncta and triggering autophagosome formation. However, the mechanisms by which these transient Ca 2+ fluctuations persist during autophagy induction, and how they are decoded to ...