Mitochondria are critical for cellular homeostasis, regulating bioenergetics, redox balance, Ca2+ signaling, and cell death.

Mitochondria are crucial organelles for cellular homeostasis, regulating processes such as ATP production, reactive oxygen ...

Aligning therapies with the biologic clock may improve efficacy, as macrophage activity peaks early in the morning, worsening inflammatory disease symptoms.

In addition, new molecular checkpoints with therapeutic potential are identified. We show that the integration of mitochondrial ... then phosphorylates ubiquitin on serine 65 (Ser65), triggering the ...

A novel mechanism that enables cells to maintain energy production even when their main power supply drops/fails has been ...

A thermal stability-based proteomic analysis identifies cytoplasmic PEBP1 as a mediator of mitochondrial dysfunction-induced stress response, highlighting its potential role in cellular adaptation ...

Accumulating data supports a paradigm whereby cerebral ischemia/reperfusion (I/R) injury is coupled with impaired mitochondrial function, contributing to the pathogenesis of ischemic stroke. Herein, ...

Disparate pathogenic mechanisms complicate precision-medicine efforts to treat diffuse large B-cell lymphoma (DLBCL), the most common lymphoma diagnosis. Though potentially curable with frontline ...