When the molecule was removed in a preclinical mouse model, several negative effects were observed, including adipose tissue insulin resistance, hyperglycemia, hyperinsulinemia, and hyperlipidemia.

A protein called B cell lymphoma 6 could be key to maintaining healthy muscle mass and potentially could be used to combat ...

In February Nature Medicine, Ellen Air and colleagues from University of Cincinnati College of Medicine, Cincinnati, Ohio, show that small molecule insulin mimetics can reduce food intake and body ...

Proteins are made of amino acids, of which there are 20 kinds. The insulin molecule comprises 51 amino acids strung together in two chains, one 21 and the other 30 amino acids long. The two chains ...

Adrenomedullin disrupts insulin signaling in blood vessels, leading to systemic insulin resistance in obesity-associated type 2 diabetes.

The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study.

Pancreatic sections were incubated with guinea pig anti-insulin (1:50) and mouse anti-glucagon (1:2000) overnight at 4°C. After several PBS washings, sections were incubated with goat anti-mouse ...

Our laboratory is focused on the function of miRNAs in control of insulin production and secretion in pancreatic beta cells. We have successfully developed a high-throughput miRNA array technology for ...