The incorporation of blood-brain barrier-like structures and immune cells, such as microglia, into these organoids allows researchers to investigate how these components influence neural ...

Researchers can easily track and isolate bit.bio's consistent, defined, and scalable human iPSC-derived cells for the first time, opening up new ...

Summary: Microglia, the brain’s immune cells, play vital roles in clearing toxins and maintaining neuronal health but can also contribute to neurodegenerative diseases if overactive. New research ...

The main immune cells in the Central Nervous System (CNS) are called microglia and can be considered the brain's resident macrophages. They are, therefore, in charge of triggering inflammation in ...

Sphere of Influence. In iAssembloids, microglia (red) form projections (white arrows), while astrocytes (green) assume star shapes typically found in the brain. [Courtesy of Kampmann et al., 2025.] ...

Finally, to examine the role of birth-induced upregulation of Glul in RG, they generated Glul-knockdown and -overexpression lentiviruses and infected them to RG in vivo. Their experiments ...

Microglia, the brain's immune cells, exhibit altered gene expression and a weakened immune response as they age, potentially contributing to neurological disorders like Alzheimer's and Parkinson's.

Jan. 15, 2025 — While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows.

The Human Microglia Atlas includes 91,716 brain immune cells covering six neurologic pathologies. It characterizes the signatures of nine populations and describes the expansion of GPNMB-high ...