By far, the best studied and most characterized inflammasome is NLRP3 inflammasome, which consists of NLRP3 (nucleotide-binding domain leucine-rich repeat (NLR) and pyrin domain containing receptor 3) ...

Nod-like receptor protein 3 (NLRP3) is a protein complex composed of multiple proteins whose formation activates cysteine aspartate protease-1 (caspase-1) to induce the maturation and secretion of ...

This valuable study on Pseudomonas subverting host immunity identifies a new immune evasion strategy. There is solid evidence for the cleavage of VgrG2B by Caspase 11 and the generation of fragments ...

This valuable study on strategies used by Pseudomonas to subvert hots immunity identifies a new immune evasion strategy. The study presents solid evidence on the cleavage of VgrG2B by Caspase 11 and ...

Expression of disease-associated hyperactive mutants of NLRP3 induces pyronecrosis. This pathway is also activated in response to intracellular infection by Shigella flexneri. Inflammation is a ...

Jupiter, Florida, Jan. 13, 2025 (GLOBE NEWSWIRE) -- Jupiter Neurosciences, Inc. (NASDAQ: JUNS) (“Jupiter” or the “Company”), a clinical-stage pharmaceutical ...

NLRP3 and NLRC4/NAIP5) NLRs that regulate other cellular responses such as type-I IFN production or MHC molecule expression (e.g., NLRC5 and NLRP12) Many NLR functions and ligands remain unknown.

The NLRP3 inflammasome is a key inflammation driver linked to central nervous system (CNS) disorders, metabolic diseases, and aging-related conditions. JOTROL, Jupiter’s flagship product ...

【导读】NLRP3介导的炎症反应在先天免疫功能中起着至关重要的作用，但NLRP3炎性小体在调节酒精性肝病（ALD）肠稳态和肠道上皮屏障方面的作用尚不 ...